Ferrying Wingless across the Synaptic Cleft
نویسندگان
چکیده
Secreted Wnt morphogens mediate cell-cell communication, but the mechanism of Wnt transfer between cells is unknown. Korkut et al. (2009) report that the transmembrane protein Evi is a versatile carrier that guides Wingless to presynaptic terminals of motor neurons and then escorts it across the synaptic cleft. In postsynaptic muscles, Evi promotes Frizzled-2 trafficking.
منابع مشابه
Activity-dependent retrograde laminin A signaling regulates synapse growth at Drosophila neuromuscular junctions.
Retrograde signals induced by synaptic activities are derived from postsynaptic cells to potentiate presynaptic properties, such as cytoskeletal dynamics, gene expression, and synaptic growth. However, it is not known whether activity-dependent retrograde signals can also depotentiate synaptic properties. Here we report that laminin A (LanA) functions as a retrograde signal to suppress synapse ...
متن کاملElectron microscopic tomography reveals discrete transcleft elements at excitatory and inhibitory synapses
Electron microscopy has revealed an abundance of material in the clefts of synapses in the mammalian brain, and the biochemical and functional characteristics of proteins occupying synaptic clefts are well documented. However, the detailed spatial organization of the proteins in the synaptic clefts remains unclear. Electron microscope tomography provides a way to delineate and map the proteins ...
متن کاملSpatio-temporal concentration of acetylcholine in vertebrate synaptic cleft
The concentration of acetylcholine (ACh) in the synaptic cleft at the neuromuscular junction (NMJ) remains impossible to quantify using direct measurements based upon spatio-temporal resolution. We present a model of the concentration of ACh in the synaptic cleft. Our model considers the release mechanism and the clearance process, represented by the hydrolysis of acetylcholinesterase (AChE) an...
متن کاملRole of Heterogeneous Macromolecular Crowding and Geometrical Irregularity at Central Excitatory Synapses in Shaping Synaptic Transmission
Besides the geometrical tortousity due to the extrasynaptic structures, macromolecular crowding and geometrical irregularities constituting the cleft composition at central excitatory synapses has a major and direct role in retarding the glutamate diffusion within the cleft space. However, the cleft composition may not only coarsely reduce the overall diffusivity of the glutamate but may also l...
متن کاملLateral assembly of the immunoglobulin protein SynCAM 1 controls its adhesive function and instructs synapse formation.
Synapses are specialized adhesion sites between neurons that are connected by protein complexes spanning the synaptic cleft. These trans-synaptic interactions can organize synapse formation, but their macromolecular properties and effects on synaptic morphology remain incompletely understood. Here, we demonstrate that the synaptic cell adhesion molecule SynCAM 1 self-assembles laterally via its...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Cell
دوره 139 شماره
صفحات -
تاریخ انتشار 2009